Manuka Honey: A Natural Approach to ER-Positive Breast Cancer
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Breast Cancer and Manuka Honey: A Promising Alternative Treatment
As of 2022, breast cancer remains the 2nd most common cancer worldwide, affecting approximately 2.3 million women. Among these cases, about 80% are estrogen receptor-positive (ER-positive), indicating a need for estrogen to grow. Traditional treatment options include surgery, chemotherapy, and hormonal therapy. However, recent research suggests that Manuka honey could offer a new avenue for prevention and treatment of ER-positive breast cancer.
Manuka Honey: Nature's Nutraceutical
Manuka honey, derived from the nectar of the Manuka tree native to Australia and New Zealand, has garnered attention for its unique nutrients and bioactive compounds. Studies have shown its potential anti-tumor effects, antioxidant properties, and wound-healing benefits. Researchers at the University of California, Los Angeles, found that Manuka honey led to an 84% reduction in tumor growth in mice with ER-positive breast cancer cells, without adverse effects on healthy cells.
Mechanisms of Action
Manuka honey's efficacy in inhibiting cancer cell growth is attributed to its impact on signaling pathways like AMP-activated protein kinase (AMPK), AKT, mTOR, and STAT3, crucial for tumor progression. By modulating these pathways, Manuka honey shows promise in targeting ER-positive breast tumors and potentially blocking cancer cell proliferation.
Potential Applications and Future Research
Further studies are needed to determine the optimal dosage and safety profile of Manuka honey for anti-tumor action. Scientists are exploring its role as a selective estrogen receptor modulator (SERM) and its ability to inhibit growth factor signaling pathways. The findings open doors for investigating Manuka honey's effects on breast cancer stem cells and its potential as a complementary therapy alongside conventional treatments.
Expert Insights and Recommendations
Medical professionals like Dr. Bhavana Pathak and nutritionists like Monique Richard acknowledge the promising nature of Manuka honey in cancer treatment. While concerns exist about its impact on glucose levels, the overall benefits warrant further exploration. With minimal side effects and potential health advantages, Manuka honey could offer a natural supplement option for individuals seeking alternative therapies.
Conclusion
The study on Manuka honey's anti-tumor effects in ER-positive breast cancer sheds light on the potential of natural compounds in cancer treatment. As research progresses, understanding the molecular pathways influenced by Manuka honey could pave the way for innovative therapeutic strategies. Incorporating this natural remedy cautiously into dietary practices may offer a holistic approach to managing breast cancer.
References
Reference: https://www.medicalnewstoday.com/articles/can-manuka-honey-help-treat-breast-cancer